News

Nature Comm publication: Mass and stiffness of E.Coli bacteria measured

Here we demonstrate that by using nanomechanical resonators, heavier analytes can be identified by their mass and stiffness. The method is demonstrated with spherical gold nanoparticles and whole intact E. Coli bacteria delivered by electrospray ionization to microcantilever resonators placed in low vacuum at 0.1 torr. We develop a theoretical procedure for obtaining the mass, position and stiffness of the analytes arriving the resonator from the adsorption-induced eigenfrequency jumps. These results demonstrate the enormous potential of this technology for identification of large biological complexes near their native conformation, a goal that is beyond the capabilities of conventional mass spectrometers. The technique can be applied also to viruses and large protein complexes.


Source: http://www.nature.com/articles/ncomms13452

Latest Posts

  • Rei Jaume I Awards Ceremony

    The King and Queen of Spain, Felipe VI and Letizia, presented the Rei Jaume I Awards at the Lonja de València. Before, a tribute to the figure of the scientist Santiago Grisolía, its founder, was held. The ceremony was also attended for the first time by two Nobel Prize winners, Finn E. Kydland and Roger…

Micro and Nanotechnology Institute
PTM – C/Isaac Newton, 8
28760 – Tres Cantos – MADRID
Tfn. (+ 34) 91 806 07 00
Fax. (+ 34) 91 806 07 01

Follow us