Javier Tamayo

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14 noviembre, 2024

Investigadores del grupo de Bionanomecánica desarrollan un método rápido y preciso para detectar células de cáncer de mama a partir de su actividad metabólica

El Grupo Bionanomechanics Lab, del Instituto de Micro y Nanotecnología del CSIC (IMN-CSIC), en colaboración con Marcos Malumbres (Vall d’Hebron Institute of Oncology (VHIO), ha desarrollado un innovador método para suprimir la principal fuente de ruido en microscopía holográfica digital que permite visualizar la actividad metabólica de las células con alta resolución espacial y alta…

Categoría	Jefe de Grupo
Cargo	RESEARCHER
Correo electrónico	jtamayo@imm.cnm.csic.es
Teléfono	+34 91 806 07 00
Website	www.imm-cnm.csic.es
Publicaciones Patentes de Investigación	Publicaciones Nanomechanical Sensing for Mass Flow Control in Nanowire-Based Open Nanofluidic Systems Square Membrane Resonators Supporting Degenerate Modes of Vibration for High-Throughput Mass Spectrometry of Single Bacterial Cells High-Throughput Mass Measurement of Single Bacterial Cells by Silicon Nitride Membrane Resonators Detection Limits in Nanomechanical Mass Flow Sensing for Nanofluidics With Nanowire Open Channels Multifrequency Nanomechanical Mass Spectrometer Prototype for measuring viral particles using optomechanical disk resonators High-throughput determination of dry mass of single bacterial cells by ultrathin membrane resonators High dynamic range nanowire resonators Nanomechanical molecular mass sensing using suspended microchannel resonators Hydrodynamic assisted multiparametric particle spectrometry A review on theory and modelling of nanomechanical sensors for biological applications Optomechanical detection of vibration modes of a single bacterium Optical Transduction for Vertical Nanowire Resonators Effects of energy metabolism on the mechanical properties of breast cancer cells. Coherent Optical Transduction of Suspended Microcapillary Resonators for Multi-Parameter Sensing Applications Mechano-Optical Analysis of Single Cells with Transparent Microcapillary Resonators Development of a methodology for reversible chemical modification of silicon surfaces with application in nanomechanical biosensors Real-Time Particle Spectrometry in Liquid Environment Using Microfluidic-Nanomechanical Resonators Nanomechanical plasmon spectroscopy of single gold nanoparticles Effect of surface stress induced curvature on the eigenfrequencies of microcantilever plates Direct Detection of OXA-48 Carbapenemase Gene in Lysate Samples through Changes in Mechanical Properties of DNA Monolayers upon Hybridization Optimization of the readout of microdrum optomechanical resonators Effect of water-DNA interactions on elastic properties of DNA self-assembled monolayers Ultrasensitive detection of HIV-1 p24 antigen by a hybrid nanomechanical-optoplasmonic platform with potential for detecting HIV-1 at first week after infection Mass and stiffness spectrometry of nanoparticles and whole intact bacteria by multimode nanomechanical resonators Spatially Multiplexed Micro-Spectrophotometry in Bright Field Mode for Thin Film Characterization Highly sensitive measurement of liquid density in air using suspended microcapillary resonators Advances and Challenges to Bring Nanomechanical Biosensors to Biochemistry Labs and Clinical Use How two-dimensional bending can extraordinarily stiffen thin sheets Optical Transduction and Actuation of Subwavelength Nanomechanical Resonators Spatially multiplexed dark-field microspectrophotometry for nanoplasmonics Effect of Actin Organization on the Stiffness of Living Breast Cancer Cells Revealed by Peak-Force Modulation Atomic Force Microscopy Label-Free DNA-Based Detection of Mycobacterium tuberculosis and Rifampicin Resistance through Hydration Induced Stress in Microcantilevers Detection of cancer biomarkers in serum using a hybrid mechanical and optoplasmonic nanosensor Hydration Induced Stress on DNA Monolayers Grafted on Microcantilevers Monitoring swelling and deswelling of thin polymer films by microcantilever sensors Physics of Nanomechanical Spectrometry of Viruses Ultrasensitive thermometer for atmospheric pressure operation based on a micromechanical resonator Silicon nanowires: where mechanics and optics meet at the nanoscale Horizontally patterned Si nanowire growth for nanomechanical devices Tapered silicon nanowires for enhanced nanomechanical sensing Atomic force microscopy reveals two phases in single stranded DNA self-assembled monolayers Interaction of viral ATPases with nucleotides measured with a microcantilever Tackling Reproducibility in Microcantilever Biosensors: A Statistical Approach for Sensitive and Specific End-point detection of Immunoreactions Optical back-action in silicon nanowire resonators: bolometric versus radiation pressure effects Biosensors based on nanomechanical systems Quantification of the surface stress in microcantilever biosensors: revisiting Stoney's equation Imaging the surface stress and vibration modes of a microcantilever by laser beam deflection microscopy Challenges for nanomechanical sensors in biological detection Monitoring the hydration of DNA self-assembled monolayers using an extensional nanomechanical resonator Stepwise motion of a microcantilever driven by the hydrolysis of viral ATPases Optomechanics with Silicon Nanowires by Harnessing Confined Electromagnetic Modes Shedding Light on Axial Stress Effect on Resonance Frequencies of Nanocantilevers Observation of spermidine-induced attractive forces in self-assembled monolayers of single stranded DNA using a microcantilever sensor Simultaneous imaging of the topography and dynamic properties of nanomechanical systems by optical beam deflection microscopy A highly sensitive microsystem based on nanomechanical biosensors for genomics applications T-shaped microcantilever with reduced deflection offset valuable for chemical and biomedical detection Dimension-dependence of the thermomechanical noise of microcantilevers Technological platforms based on micro/nanobiosensors as early warning systems for biological/chemical warfare. In Defence against Bioterror: Detection Technologies, Implementation, Strategies and Commercial Opportunities Real-time profile of microcantilevers for sensing applications Nanomechanical Biosensors. Encyclopedia of Sensors. Study of the noise of micromechanical oscillators under quality factor enhancement Optical sequential readout of microcantilever arrays for biological detection Nanomechanics of the formation of DNA self-assembled monolayers and hybridisation on microcantilevers Nanomechanics for specific biological detection Decrease of the resonance bandwidth of micromechanical oscillators by phase-control of the driving force Digital tuning of the quality factor of micromechanical resonant biological detectors Polymeric cantilever arrays for biosensing applications Exponential tuning of the coupling constant of coupled microcantilevers by modifying their separation High throughput optical readout of dense arrays of nanomechanical systems for sensing applications Highly sensitive polymer-based cantilever-sensors for DNA detection Nanomechanical mass sensing and stiffness spectrometry based on two-dimensional vibrations of resonant nanowires Low-noise polymeric nanomechanical biosensors Photothermal excitation of microcantilevers in liquids Study of the adsorption of sulfur-derivatized single stranded DNA on gold by atomic force microscopy and the cantilever bending technique Origin of the response of nanomechanical resonators to bacteria adsorption Effect of the adsorbate stiffness on the resonance response of microcantilevers Role of the gold film nanostructure on the nanomechanical response of microcantilever sensors Study of the origin of bending induced by bimetallic effect on microcantilevers Measurement of the mass and rigidity of adsorbates on a microcantilever sensor Underlying mechanisms of the self-sustained-oscillation of a nanomechanical stochastic resonator in a liquid Detection of bacteria on the thermomechanical noise of a nanomechanical resonator: Origin of the response and detection limits Label-free detection of DNA hybridization based on hydration-induced tension in nucleic acid films Phototermal self-excitation of nanomechanical resonators in liquids Arrays of dual nanomechanical resonators for selective biological detection Development of nanomechanical biosensors for detection of the pesticide DDT Mass Sensing Based on Deterministic and Stochastic Responses of Elastically Coupled Nanocantilevers, Measurement of the mass and rigidity of adsorbates on a microcantilever sensor Nanomechanical sensors– Inside tracks weighs in with solution Patentes de Investigación SISTEMA DE ANÁLISIS MECANO-ÓPTICO, MÉTODO DE FABRICACION DEL MISMO, USO PARA IDENTIFICACIÓN Y CLASIFICACIÓN DE POBLACIONES CELULARES Y PROCEDIMIENTO DE ANÁLISIS MECANO-ÓPTICO METHOD FOR OBTAINING THE ABSORPTION POSITION, MASS AND RIGIDITY OF A PARTICLE ESPECTROFOTOMETRO UN SISTEMA PARA APLICACIONES DE BIODETECCIÓN MÉTODO Y SISTEMA DE CARACTERIZACIÓN DE ESTRUCTURAS NANO Y MICRO MECÁNICAS Method for bionalysis of nucleic acids in a sample and biosensor for its implementation. System and method for detecting the displacement of a plurality of micro- and nanomechanical elements, such as microcantilevers. System and method for surface inspection of micro- and nanomechanical structures. Method and system for detection of a selected type of molecules in a sample.

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Investigadores del grupo de Bionanomecánica desarrollan un método rápido y preciso para detectar células de cáncer de mama a partir de su actividad metabólica

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