Bionanomecánica

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14 noviembre, 2024

Investigadores del grupo de Bionanomecánica desarrollan un método rápido y preciso para detectar células de cáncer de mama a partir de su actividad metabólica

El Grupo Bionanomechanics Lab, del Instituto de Micro y Nanotecnología del CSIC (IMN-CSIC), en colaboración con Marcos Malumbres (Vall d’Hebron Institute of Oncology (VHIO), ha desarrollado un innovador método para suprimir la principal fuente de ruido en microscopía holográfica digital que permite visualizar la actividad metabólica de las células con alta resolución espacial y alta…

Descripción	El grupo de Bionanomecánica se estableció en el año 2005 con el objetivo de desarrollar herramientas analíticas innovadoras basadas en nanotecnología para aplicaciones biológicas y con especial énfasis en los sensores nanomecánicos.
Website	bionano.imn-cnm.csic.es
Líneas de Investigación Areas de Investigación Proyectos de Investigación Laboratorios Patentes Publicaciones	Líneas de Investigación Teoría y modelización Propiedades mecánicas de células Biochips nanomecánicos Optomecánica Resonadores nanomecánicos acoplados Sensores nanomecánicos multiparámetro Areas de Investigación Micro y Nanotecnología Proyectos de Investigación DISOM: Detección Inmediata de la infección por SARS-CoV-2 mediante prueba de aire exhalado basada en sensores Opto-Mecánicos OPTOCAP: Diagnóstico inmediato y universal de enfermedades infecciosas basado en capilares optomecánicos BIOPTOMEC: Resonadores optomecánicos para aplicaciones biológicas MICROBIOMS: Espectroscopia mecanica de entidades biologicas basada en resonadores optomecánicos Ultrasensitive nanosensor for the detection of breast cancer with a blood test RTC-2017-6311-1: NUEVA PLATAFORMA HÍPER-ESPECTRAL PARA LA DETECCIÓN SIMULTÁNEA Y ULTRASENSIBLE DE MARCADORES INFECCIOSOS EN DONACIONES DE SANGRE NANO_PROST: Desarrollo de una tecnología ultrasensible de sensado nanomecánico para el diagnóstico de cáncer de próstata en el punto de atención. RTC-2016-4776-1. Sistemas Nano-optomecanicos aplicados como sensores biologicos Optomechanics for Virology VIRUSCAN High throughput mass spectrometry of single proteins in liquid environment LIQUIDMASS Sensor nanomecánico para el diagnóstico del cáncer de pulmón INMUNO-swing (IPT-2011-0821-010000) NEMS avanzados con aplicaciones a la detección biológica ultrasensible (ANEM!). TEC2009-14517-C02-02 Cavidades optomecánicas en fluidos para detección ultrasensible de masa. OPTONANOMECH (FP7-PEOPLE-2009-IOF-254996) Análisis De Estructura y Función de Nanomáquinas y otros sistemas biológicos y su integración en Dispositivos Nanomecánicos mediante técnicas de manipulación de moléculas individuales(2ª Parte) NOBIMAT-M Dispositivos nanomecánicos para detección biológica ultrasensible Detección nanomecánica de virus y bacterias y seguimiento de su interacción con fármacos NEMS avanzados con aplicaciones a la detección biológica ultrasensible (ANEM!). TEC2009-14517-C02-02 Nanoestructuras para la optimización de un sistema óptico de lectura mediante interferometría Nanociencia molecular Sistemas nanoelectromecánicos basados en nanohilos de silicio (NANOSi) Desarrollo de sistemas híbridos bio-inorgánicos que integren bionanomáquinas en dispositivos nanomecánicos Nanobiosensores con tecnología MEMS/NEMS para la detección de ADN y agentes infecciosos (NANOMECANOSEN). TEC2006-10316 Desarrollo de un dispositivo nanomecánico para detección biológica. 200550M056. Análisis De Estructura y Función de Nanomáquinas y otros sistemas biológicos y su integración en Dispositivos Nanomecánicos mediante técnicas de manipulación de moléculas individuales. S-0505/MAT-0283 Biosensor opto-nanomecánico integrado para análisis en genómica funcional. IST2001-37239 Desarrollo de tecnologías de genómica y proteómica funcional y sus aplicaciones al estudio del desarrollo de enfermedad. Subproyecto 12: Desarrollo de nanobiochips de ADN. GEN2001-4856-C13-11 Sensor nanomecánico para el diagnóstico del cáncer de pulmón INMUNO-swing (IPT-2011-0821-010000) Dispositivos nanomecánicos para detección biológica ultrasensible Proyecto de Investigación fundamental orientada a la Transmisión de Conocimiento a la Empresa (T.R.A.C.E.). TRA2009_0117. Aplicación de la tecnología de sensores nanomecánicos para el estudio de las propiedades mecánicas de células tumorales Desarrollo de herramientas nanomecánicas para la investigación de la mecánica celular NANOFORCELLS Capas delgadas poliméricas en biosensores nanomecánicos para detección multianalito Laboratorios Equipo para inyección de microgotas Microscopio de fluorescencia Interferómetro de luz blanca, Wyko, Veeco Microscopio de fuerzas atómicas, Veeco Sistemas para la caracterización en líquidos Sistema de barrido láser para la lectura de cientos de micropalancas Interferómetro para la caracterización de nanopalancas y nanohilos Patentes METHOD FOR OBTAINING THE ABSORPTION POSITION, MASS AND RIGIDITY OF A PARTICLE ESPECTROFOTOMETRO UN SISTEMA PARA APLICACIONES DE BIODETECCIÓN MÉTODO Y SISTEMA DE CARACTERIZACIÓN DE ESTRUCTURAS NANO Y MICRO MECÁNICAS Method for bionalysis of nucleic acids in a sample and biosensor for its implementation. Cantilever with polymer composite strain sensor. Integrated optical readout of cantilever sensors. Microfluid sample delivery system. System and method for detecting the displacement of a plurality of micro- and nanomechanical elements, such as microcantilevers. Polymer-based cantilever array with optical read-out. System and method for surface inspection of micro- and nanomechanical structures. Method and system for detection of a selected type of molecules in a sample. Publicaciones High-throughput determination of dry mass of single bacterial cells by ultrathin membrane resonators Optomechanical detection of vibration modes of a single bacterium Optical Transduction for Vertical Nanowire Resonators Effects of energy metabolism on the mechanical properties of breast cancer cells. Mechano-Optical Analysis of Single Cells with Transparent Microcapillary Resonators Development of a methodology for reversible chemical modification of silicon surfaces with application in nanomechanical biosensors Real-Time Particle Spectrometry in Liquid Environment Using Microfluidic-Nanomechanical Resonators Nanomechanical plasmon spectroscopy of single gold nanoparticles Effect of surface stress induced curvature on the eigenfrequencies of microcantilever plates Direct Detection of OXA-48 Carbapenemase Gene in Lysate Samples through Changes in Mechanical Properties of DNA Monolayers upon Hybridization Optimization of the readout of microdrum optomechanical resonators Nanomechanical properties of composite protein networks of erythroid membranes at lipid surfaces Effect of water-DNA interactions on elastic properties of DNA self-assembled monolayers Ultrasensitive detection of HIV-1 p24 antigen by a hybrid nanomechanical-optoplasmonic platform with potential for detecting HIV-1 at first week after infection Mass and stiffness spectrometry of nanoparticles and whole intact bacteria by multimode nanomechanical resonators Intracellular pH-Induced Tip-to-Tip Assembly of Gold Nanorods for Enhanced Plasmonic Photothermal Therapy Spatially Multiplexed Micro-Spectrophotometry in Bright Field Mode for Thin Film Characterization Highly sensitive measurement of liquid density in air using suspended microcapillary resonators Advances and Challenges to Bring Nanomechanical Biosensors to Biochemistry Labs and Clinical Use How two-dimensional bending can extraordinarily stiffen thin sheets Optical Transduction and Actuation of Subwavelength Nanomechanical Resonators Spatially multiplexed dark-field microspectrophotometry for nanoplasmonics Effect of Actin Organization on the Stiffness of Living Breast Cancer Cells Revealed by Peak-Force Modulation Atomic Force Microscopy Silicon-nanowire based attachment of silicon chips for mouse embryo labelling Label-Free DNA-Based Detection of Mycobacterium tuberculosis and Rifampicin Resistance through Hydration Induced Stress in Microcantilevers Detection of cancer biomarkers in serum using a hybrid mechanical and optoplasmonic nanosensor Hydration Induced Stress on DNA Monolayers Grafted on Microcantilevers Improved thermal behavior of multiple linked arrays of silicon nanowires integrated into planar thermoelectric microgenerators High-sensitivity linear piezoresistive transduction for nanomechanical beam resonators Monitoring swelling and deswelling of thin polymer films by microcantilever sensors Physics of Nanomechanical Spectrometry of Viruses Ultrasensitive thermometer for atmospheric pressure operation based on a micromechanical resonator Silicon nanowires: where mechanics and optics meet at the nanoscale Horizontally patterned Si nanowire growth for nanomechanical devices Fabrication and Mechanical Characterization of Semi-Free-Standing (Conjugated) Polymer Thin Films Tapered silicon nanowires for enhanced nanomechanical sensing Atomic force microscopy reveals two phases in single stranded DNA self-assembled monolayers Interaction of viral ATPases with nucleotides measured with a microcantilever Tackling Reproducibility in Microcantilever Biosensors: A Statistical Approach for Sensitive and Specific End-point detection of Immunoreactions Optical back-action in silicon nanowire resonators: bolometric versus radiation pressure effects Biosensors based on nanomechanical systems Quantification of the surface stress in microcantilever biosensors: revisiting Stoney's equation Imaging the surface stress and vibration modes of a microcantilever by laser beam deflection microscopy Challenges for nanomechanical sensors in biological detection Monitoring the hydration of DNA self-assembled monolayers using an extensional nanomechanical resonator Stepwise motion of a microcantilever driven by the hydrolysis of viral ATPases Optomechanics with Silicon Nanowires by Harnessing Confined Electromagnetic Modes Shedding Light on Axial Stress Effect on Resonance Frequencies of Nanocantilevers Observation of spermidine-induced attractive forces in self-assembled monolayers of single stranded DNA using a microcantilever sensor Simultaneous imaging of the topography and dynamic properties of nanomechanical systems by optical beam deflection microscopy A highly sensitive microsystem based on nanomechanical biosensors for genomics applications T-shaped microcantilever with reduced deflection offset valuable for chemical and biomedical detection Dimension-dependence of the thermomechanical noise of microcantilevers Technological platforms based on micro/nanobiosensors as early warning systems for biological/chemical warfare. In Defence against Bioterror: Detection Technologies, Implementation, Strategies and Commercial Opportunities Real-time profile of microcantilevers for sensing applications Nanomechanical Biosensors. Encyclopedia of Sensors. Study of the noise of micromechanical oscillators under quality factor enhancement Optical sequential readout of microcantilever arrays for biological detection Nanomechanics of the formation of DNA self-assembled monolayers and hybridisation on microcantilevers Nanomechanics for specific biological detection Decrease of the resonance bandwidth of micromechanical oscillators by phase-control of the driving force Digital tuning of the quality factor of micromechanical resonant biological detectors Polymeric cantilever arrays for biosensing applications Exponential tuning of the coupling constant of coupled microcantilevers by modifying their separation High throughput optical readout of dense arrays of nanomechanical systems for sensing applications Highly sensitive polymer-based cantilever-sensors for DNA detection Nanomechanical mass sensing and stiffness spectrometry based on two-dimensional vibrations of resonant nanowires Investigation of the bond strength between the photo-sensitive polymer SU-8 and Au Low-noise polymeric nanomechanical biosensors Photothermal excitation of microcantilevers in liquids Study of the adsorption of sulfur-derivatized single stranded DNA on gold by atomic force microscopy and the cantilever bending technique Origin of the response of nanomechanical resonators to bacteria adsorption Effect of the adsorbate stiffness on the resonance response of microcantilevers Role of the gold film nanostructure on the nanomechanical response of microcantilever sensors Integrated optical read-out for miniaturisation of cantilever-based biosensors Novel fabrication technique for free-hanging homogeneous polymeric cantilever waveguides Study of the origin of bending induced by bimetallic effect on microcantilevers Measurement of the mass and rigidity of adsorbates on a microcantilever sensor Underlying mechanisms of the self-sustained-oscillation of a nanomechanical stochastic resonator in a liquid Detection of bacteria on the thermomechanical noise of a nanomechanical resonator: Origin of the response and detection limits Label-free detection of DNA hybridization based on hydration-induced tension in nucleic acid films Phototermal self-excitation of nanomechanical resonators in liquids Arrays of dual nanomechanical resonators for selective biological detection Development of nanomechanical biosensors for detection of the pesticide DDT Mass Sensing Based on Deterministic and Stochastic Responses of Elastically Coupled Nanocantilevers, Measurement of the mass and rigidity of adsorbates on a microcantilever sensor Nanomechanical sensors– Inside tracks weighs in with solution Measuring more than mass

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Investigadores del grupo de Bionanomecánica desarrollan un método rápido y preciso para detectar células de cáncer de mama a partir de su actividad metabólica

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