Bionanomechanics

Bionanomechanics Lab researchers develop a fast and accurate method to detect breast cancer cells from their metabolic activity

Bionanomechanics Lab Group of the Institute of Micro and Nanotechnology of the CSIC (IMN-CSIC), in collaboration with Marcos Malumbres (Vall d’Hebron Institute of Oncology (VHIO), has developed an innovative method to suppress the main source of noise in digital holographic microscopy that allows visualization of the metabolic activity of cells with high spatial resolution and…

Description	The Bionanomechanics group was established in 2005 with the aim of developing novel analytical tools based in nanotechnology for biological applications and with a focus in nanomechanical sensing.
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Research Lines Research Areas Research Projects Laboratories Patents Research Works	Research Lines Theory and modelling Cell nanomechanics Nanomechanical biochips Optomechanics Coupled nanomechanical resonators Multifunctional nanomechanical systems Research Areas Micro and Nano Technology Research Projects DISOM: Immediate Detection of SARS-CoV-2 Infection Using Exhaled Air Test Based on Opto-Mechanical Sensors OPTOCAP: Immediate and universal diagnosis of infectious diseases based on optomechanical capillaries BIOPTOMEC: Optomechanical resonators for biological applications MICROBIOMS: Mechanical spectroscopy of microbiological entities based on optomechanical sensors Ultrasensitive nanosensor for the detection of breast cancer with a blood test RTC-2017-6311-1: NEW HYPER-SPECTRAL PLATFORM FOR THE SIMULTANEOUS AND ULTRASENSIBLE DETECTION OF INFECTIOUS MARKERS IN BLOOD DONATIONS NANO_PROST: Development of an ultrasensitive nanomechanical sensing technology for the diagnosis of prostate cancer at the point of care. RTC-2016-4776-1-P01 Nano-OptoMechanical Systems for Biological Sensors Optomechanics for Virology VIRUSCAN High throughput mass spectrometry of single proteins in liquid environment LIQUIDMASS Nanomechanical sensor for lung cancer diagnosis INMUNO-Swing (IPT-2011-0821-010000) Advanced NEMS for highly sensitive biological detection (ANEM!). TEC2009-14517-C02-02 Operation of cavity optomechanics in fluids for ultrasensitive mass detection. OPTONANOMECH (FP7-PEOPLE-2009-IOF-254996) Structural and functional analysis of nanomachines and other biological systems and their integration in nanomechanical devices by single molecule manipulation (Part II) Nanomechanical devices for highly sensitive biological detection Nanomechanical detection of virus and bacteria and drug interactions Advanced NEMS with applications to ultrasensitive biological detection(ANEM!). TEC2009-14517-C02-02 Nanostructures for optimization of an optical interferometer Molecular Nanoscience Nanoelectromechanical systems based on silicon nanowires (NANOSi) Development of bio-inorganic hybrid systems for bionanomachine integration in nanomechanical devices MEMS/NEMS biosensors for DNa and pathogen detection. TEC2006-10316 Development of nanomechanical device for bilogical detection. 200550M056 Analysis of the structure and function of nanomachines and biological systems and integration in nanomechanical devices by individual molecule manipulation. S-0505/MAT-0283 Integrated Opto-Nanomechanical biosensor for functional genomic analysis. IST2001-37239 Development of functional genomics and proteomics technologies and their applications to the study of disease development. Subproject 12: Development of DNA Nanobiochips. GEN2001-4856-C13-11 Nanomechanical sensor for lung cancer diagnosis INMUNO-Swing (IPT-2011-0821-010000) Nanomechanical devices for highly sensitive nanomechanical detection Nanomechnaical sensors applied to follow mechanical properties of cancer cells Development of a nanomechanical tool-box for the investigation of cell mechanics NANOFORCELLS Thin polymer films for multianalyte detection Laboratories Inkjetting set up for patterning of biomolecules on solid supports and functionalization of large nanomechanical arrays. Fluorescence microscope White light Interferometer microscope, Wyko, Veeco Atomic Force Microscope, Veeco Systems for real-time characterization in liquids Laser scanning system for the read-out of hundreds of microcantilevers Interferometer for nanocantilever and nanowire characterization Patents METHOD FOR OBTAINING THE ABSORPTION POSITION, MASS AND RIGIDITY OF A PARTICLE ESPECTROFOTOMETRO UN SISTEMA PARA APLICACIONES DE BIODETECCIÓN MÉTODO Y SISTEMA DE CARACTERIZACIÓN DE ESTRUCTURAS NANO Y MICRO MECÁNICAS Method for bionalysis of nucleic acids in a sample and biosensor for its implementation. Cantilever with polymer composite strain sensor. Integrated optical readout of cantilever sensors. Microfluid sample delivery system. System and method for detecting the displacement of a plurality of micro- and nanomechanical elements, such as microcantilevers. Polymer-based cantilever array with optical read-out. System and method for surface inspection of micro- and nanomechanical structures. Method and system for detection of a selected type of molecules in a sample. Research Works High-throughput determination of dry mass of single bacterial cells by ultrathin membrane resonators Optomechanical detection of vibration modes of a single bacterium Optical Transduction for Vertical Nanowire Resonators Effects of energy metabolism on the mechanical properties of breast cancer cells. Mechano-Optical Analysis of Single Cells with Transparent Microcapillary Resonators Development of a methodology for reversible chemical modification of silicon surfaces with application in nanomechanical biosensors Real-Time Particle Spectrometry in Liquid Environment Using Microfluidic-Nanomechanical Resonators Nanomechanical plasmon spectroscopy of single gold nanoparticles Effect of surface stress induced curvature on the eigenfrequencies of microcantilever plates Direct Detection of OXA-48 Carbapenemase Gene in Lysate Samples through Changes in Mechanical Properties of DNA Monolayers upon Hybridization Optimization of the readout of microdrum optomechanical resonators Nanomechanical properties of composite protein networks of erythroid membranes at lipid surfaces Effect of water-DNA interactions on elastic properties of DNA self-assembled monolayers Ultrasensitive detection of HIV-1 p24 antigen by a hybrid nanomechanical-optoplasmonic platform with potential for detecting HIV-1 at first week after infection Mass and stiffness spectrometry of nanoparticles and whole intact bacteria by multimode nanomechanical resonators Intracellular pH-Induced Tip-to-Tip Assembly of Gold Nanorods for Enhanced Plasmonic Photothermal Therapy Spatially Multiplexed Micro-Spectrophotometry in Bright Field Mode for Thin Film Characterization Highly sensitive measurement of liquid density in air using suspended microcapillary resonators Advances and Challenges to Bring Nanomechanical Biosensors to Biochemistry Labs and Clinical Use How two-dimensional bending can extraordinarily stiffen thin sheets Optical Transduction and Actuation of Subwavelength Nanomechanical Resonators Spatially multiplexed dark-field microspectrophotometry for nanoplasmonics Effect of Actin Organization on the Stiffness of Living Breast Cancer Cells Revealed by Peak-Force Modulation Atomic Force Microscopy Silicon-nanowire based attachment of silicon chips for mouse embryo labelling Label-Free DNA-Based Detection of Mycobacterium tuberculosis and Rifampicin Resistance through Hydration Induced Stress in Microcantilevers Detection of cancer biomarkers in serum using a hybrid mechanical and optoplasmonic nanosensor Hydration Induced Stress on DNA Monolayers Grafted on Microcantilevers Improved thermal behavior of multiple linked arrays of silicon nanowires integrated into planar thermoelectric microgenerators High-sensitivity linear piezoresistive transduction for nanomechanical beam resonators Monitoring swelling and deswelling of thin polymer films by microcantilever sensors Physics of Nanomechanical Spectrometry of Viruses Ultrasensitive thermometer for atmospheric pressure operation based on a micromechanical resonator Silicon nanowires: where mechanics and optics meet at the nanoscale Horizontally patterned Si nanowire growth for nanomechanical devices Fabrication and Mechanical Characterization of Semi-Free-Standing (Conjugated) Polymer Thin Films Tapered silicon nanowires for enhanced nanomechanical sensing Atomic force microscopy reveals two phases in single stranded DNA self-assembled monolayers Interaction of viral ATPases with nucleotides measured with a microcantilever Tackling Reproducibility in Microcantilever Biosensors: A Statistical Approach for Sensitive and Specific End-point detection of Immunoreactions Optical back-action in silicon nanowire resonators: bolometric versus radiation pressure effects Biosensors based on nanomechanical systems Quantification of the surface stress in microcantilever biosensors: revisiting Stoney's equation Imaging the surface stress and vibration modes of a microcantilever by laser beam deflection microscopy Challenges for nanomechanical sensors in biological detection Monitoring the hydration of DNA self-assembled monolayers using an extensional nanomechanical resonator Stepwise motion of a microcantilever driven by the hydrolysis of viral ATPases Optomechanics with Silicon Nanowires by Harnessing Confined Electromagnetic Modes Shedding Light on Axial Stress Effect on Resonance Frequencies of Nanocantilevers Observation of spermidine-induced attractive forces in self-assembled monolayers of single stranded DNA using a microcantilever sensor Simultaneous imaging of the topography and dynamic properties of nanomechanical systems by optical beam deflection microscopy A highly sensitive microsystem based on nanomechanical biosensors for genomics applications T-shaped microcantilever with reduced deflection offset valuable for chemical and biomedical detection Dimension-dependence of the thermomechanical noise of microcantilevers Technological platforms based on micro/nanobiosensors as early warning systems for biological/chemical warfare. In Defence against Bioterror: Detection Technologies, Implementation, Strategies and Commercial Opportunities Real-time profile of microcantilevers for sensing applications Nanomechanical Biosensors. Encyclopedia of Sensors. Study of the noise of micromechanical oscillators under quality factor enhancement Optical sequential readout of microcantilever arrays for biological detection Nanomechanics of the formation of DNA self-assembled monolayers and hybridisation on microcantilevers Nanomechanics for specific biological detection Decrease of the resonance bandwidth of micromechanical oscillators by phase-control of the driving force Digital tuning of the quality factor of micromechanical resonant biological detectors Polymeric cantilever arrays for biosensing applications Exponential tuning of the coupling constant of coupled microcantilevers by modifying their separation High throughput optical readout of dense arrays of nanomechanical systems for sensing applications Highly sensitive polymer-based cantilever-sensors for DNA detection Nanomechanical mass sensing and stiffness spectrometry based on two-dimensional vibrations of resonant nanowires Investigation of the bond strength between the photo-sensitive polymer SU-8 and Au Low-noise polymeric nanomechanical biosensors Photothermal excitation of microcantilevers in liquids Study of the adsorption of sulfur-derivatized single stranded DNA on gold by atomic force microscopy and the cantilever bending technique Origin of the response of nanomechanical resonators to bacteria adsorption Effect of the adsorbate stiffness on the resonance response of microcantilevers Role of the gold film nanostructure on the nanomechanical response of microcantilever sensors Integrated optical read-out for miniaturisation of cantilever-based biosensors Novel fabrication technique for free-hanging homogeneous polymeric cantilever waveguides Study of the origin of bending induced by bimetallic effect on microcantilevers Measurement of the mass and rigidity of adsorbates on a microcantilever sensor Underlying mechanisms of the self-sustained-oscillation of a nanomechanical stochastic resonator in a liquid Detection of bacteria on the thermomechanical noise of a nanomechanical resonator: Origin of the response and detection limits Label-free detection of DNA hybridization based on hydration-induced tension in nucleic acid films Phototermal self-excitation of nanomechanical resonators in liquids Arrays of dual nanomechanical resonators for selective biological detection Development of nanomechanical biosensors for detection of the pesticide DDT Mass Sensing Based on Deterministic and Stochastic Responses of Elastically Coupled Nanocantilevers, Measurement of the mass and rigidity of adsorbates on a microcantilever sensor Nanomechanical sensors– Inside tracks weighs in with solution Measuring more than mass

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