Open

Open Post doctoral position to work on High throughput mass spectrometry of single proteins in liquid environment

Research AreaMicro and Nano Technology
Description

Addressed to

Experienced researchers in Physics. Candidates must have previous experience in related topics and an excellent publication record.

Description

This position is offered in the frame of the ERC Consolidator Grant project LIQUIDMASS.

The goal of the project is to develop a high throughput spectrometric technique addressing single proteins from complex samples, while in physiological conditions. LIQUIDMASS also proposes a new concept for protein spectrometry, by characterizing not only the mass, but also the hydrodynamic radius, geometry and stiffness of single proteins. This multiparameter approach will serve to open up new routes to understand protein structure-function relations by providing insight into the fast conformational changes that occur in liquids. In order to attain these goals, I propose to integrate nanomechanical resonators, nano-optics and nanofluidics. The disruptive approach proposed will bring about new knowledge about protein interactions and protein conformation that is elusive today. The enabling technologies aimed at the LIQUIDMASS will increase our understanding of protein misfolding related diseases, such as Alzheimer’s or diabetes, as well as bring closer a full understanding of the human interactome, contributing to the advancement of the proteomics field. 

A contract for one year is offered, with further extension to 5 years.

Contact:

Dr. Montserrat Calleja

mcalleja@imm.cnm.csic.es 

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